The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

Abstract

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).

Artículo completo: https://www.ncbi.nlm.nih.gov/pubmed/19608284

ARTICULOS

cannabis de esperanza

Naciones Unidas trabaja en facilitar “la investigación y comercio de cannabis mundial” (FAAAT Carta Abierta)

La primera publicidad educativa cannábica aprobada en Londres (TRADUCCIÓN)

Cannabis medicinal: reglamento del Minsa aún margina a pacientes (LA ENTREVISTA)

Perú: Convenio Dará Cannabis Medicinal Sin Costo a Pacientes de Bajos Recursos

Encuesta Federal Identifica Notorio Decrecimiento en El Uso de Marihuana en Gente Joven (TRADUCCIÓN)

LA ONU Y LA OMS CIERRAN 60 AÑOS DE PARÉNTESIS OSCURANTISTA (PARTE 1)

VIDEOS

Cannabis Medicinal y Fibromialgia: El Camino de Libertad

El científico (The Scientist – subtitulos en español)

Primera Charla Gratuita Cannabis Medicinal, Dr. Dave Hepburn MD

Cannabis Medicinal y Fibromialgia: El Camino de Libertad

El científico (The Scientist – subtitulos en español)

Primera Charla Gratuita Cannabis Medicinal, Dr. Dave Hepburn MD

Open chat