Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for the treatment of these tumors are currently being investigated. Given the growth-inhibiting effects of cannabinoids on gliomas and the wide tissue distribution of the two subtypes of cannabinoid receptors (CB(1) and CB(2)), we studied the potential utility of these compounds in anti-skin tumor therapy. Here we show that the CB(1) and the CB(2) receptor are expressed in normal skin and skin tumors of mice and humans. In cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells remained unaffected. Local administration of the mixed CB(1)/CB(2) agonist WIN-55,212-2 or the selective CB(2) agonist JWH-133 induced a considerable growth inhibition of malignant tumors generated by inoculation of epidermal tumor cells into nude mice. Cannabinoid-treated tumors showed an increased number of apoptotic cells. This was accompanied by impairment of tumor vascularization, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors.

Artículo completo: https://www.ncbi.nlm.nih.gov/pubmed/12511587

ARTICULOS

cannabis de esperanza

Naciones Unidas trabaja en facilitar “la investigación y comercio de cannabis mundial” (FAAAT Carta Abierta)

La primera publicidad educativa cannábica aprobada en Londres (TRADUCCIÓN)

Cannabis medicinal: reglamento del Minsa aún margina a pacientes (LA ENTREVISTA)

Perú: Convenio Dará Cannabis Medicinal Sin Costo a Pacientes de Bajos Recursos

Encuesta Federal Identifica Notorio Decrecimiento en El Uso de Marihuana en Gente Joven (TRADUCCIÓN)

LA ONU Y LA OMS CIERRAN 60 AÑOS DE PARÉNTESIS OSCURANTISTA (PARTE 1)

VIDEOS

Cannabis Medicinal y Fibromialgia: El Camino de Libertad

El científico (The Scientist – subtitulos en español)

Primera Charla Gratuita Cannabis Medicinal, Dr. Dave Hepburn MD

Cannabis Medicinal y Fibromialgia: El Camino de Libertad

El científico (The Scientist – subtitulos en español)

Primera Charla Gratuita Cannabis Medicinal, Dr. Dave Hepburn MD

Open chat